Advanced Oxygen Therapy, Inc. (AOTI) offers the only multi-modality topical oxygen wound therapy (TWO2) on the market. This FDA cleared therapy uses a combination of non-contact cyclical compression, humidification and high-pressure delivery of oxygen to the wound bed resulting in more effective and durable healing. TWO2 therapy is proven in both randomized controlled trials and real-world evidence to reduce hospitalizations and amputations. TWO2 can be administered in any clinical setting or at home by patients, over-coming common barriers to access and compliance. More than 2 million treatments have been administered to date.